PROpeg — Copyright and Attribution

Copyright (c) 2026 ICAR-Central Rice Research Institute (CRRI), Cuttack and
ICAR-Indian Agricultural Statistics Research Institute (IASRI), New Delhi.


Algorithmic basis
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The pegRNA design procedure implements the approach described in:

  Lin, Q., Jin, S., Zong, Y. et al. High-efficiency prime editing with optimized
  extended pegRNAs in rice and wheat. Nature Biotechnology 39, 923-927 (2021).
  https://doi.org/10.1038/s41587-021-00868-w


Third-party components
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Bundled or integrated third-party software retains its own original license:

  - pegLIT — BSD 3-Clause (Broad Institute & Harvard, 2023)
    See: ext_tools/peglit/LICENSE
    Nelson, J.W. et al. Nature Biotechnology 40, 402-410 (2022).

  - PRIDICT2.0 — MIT (Krauthammer Lab & Schwank Lab)
    See: ext_tools/PRIDICT2/LICENSE
    Mathis, N. et al. Nature Biotechnology (2024).

  - pegFinder — MIT (Copyright (c) 2020 rdchow)
    The PE3/PE3b nicking-sgRNA logic in peg_core.py is a port of pegFinder; the
    upstream MIT copyright and permission notice is retained inline in that file.
    Chow, R.D. et al. Nature Biomedical Engineering 5, 190-194 (2021).